{"id":10668,"date":"2024-08-08T16:53:39","date_gmt":"2024-08-08T21:53:39","guid":{"rendered":"https:\/\/www.voicesforvaccines.org\/?post_type=jtf_topics&#038;p=10668"},"modified":"2024-08-12T15:05:13","modified_gmt":"2024-08-12T20:05:13","slug":"why-arent-vaccines-tested-against-placebos","status":"publish","type":"jtf_topics","link":"https:\/\/www.voicesforvaccines.org\/es\/jtf_topics\/why-arent-vaccines-tested-against-placebos\/","title":{"rendered":"Were vaccines tested against placebos?"},"content":{"rendered":"<div class=\"wpb-content-wrapper\">[vc_row source=&#8221;&#8221; text=&#8221;Clinical Trials&#8221; font_container=&#8221;tag:h2|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; google_fonts=&#8221;font_family:Abril%20Fatface%3Aregular|font_style:400%20regular%3A400%3Anormal&#8221; link=&#8221;&#8221; css=&#8221;.vc_custom_1708910874436{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;}&#8221;][vc_column][vc_row_inner][vc_column_inner][vc_custom_heading text=&#8221;The Claim:&#8221; font_container=&#8221;tag:h3|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221;][vc_column_text css=&#8221;&#8221;]\n<div class=\"vc_row wpb_row vc_inner vc_row-fluid\">\n<div class=\"wpb_column vc_column_container vc_col-sm-12\">\n<div class=\"vc_column-inner\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<p>An RFK Jr.\u00a0<a href=\"https:\/\/x.com\/RobertKennedyJr\/status\/1819855873801392393\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3Dffc92c5e9b%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1723578396477000&amp;usg=AOvVaw0sVW8twJxHsMWOm7XnEa6h\">tweet<\/a>\u00a0claims that none of\u00a0<span class=\"il\">the<\/span>\u00a0vaccines given to children in\u00a0<span class=\"il\">the<\/span>\u00a0U.S. were tested in a &#8220;long-term placebo-controlled&#8221; trial.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner][vc_custom_heading text=&#8221;The Facts:&#8221; font_container=&#8221;tag:h3|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221;][vc_column_text css=&#8221;&#8221;]<span class=\"il\">The<\/span>\u00a0tweet claims that most childhood vaccine trials use other vaccines as controls, which are immunologically active and not inert placebos. In reality, saline-placebo-controlled trials are conducted for many vaccines to assess both\u00a0<a href=\"https:\/\/www.voicesforvaccines.org\/toolkits\/vaccine-overview-development-safety\/\">safety<\/a>\u00a0and efficacy:<\/p>\n<ul>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9142061\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D9b4a4b97e3%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw32oSp_dVw5AFEA2hLObqz2\">Rubella<\/a>\u00a0vaccine<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3893185\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D1314eaff2f%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw2PV3wc84z5i8otVAT5ijJB\">Pneumococcal<\/a>\u00a0vaccine<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2233906\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3Dd9bfacac6f%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw3B47LWEmeZJ9UFuSp41fnZ\">Hib<\/a>\u00a0vaccines<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17484215\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D0a8f83150d%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw3S7pEL9M4FoVxfSXW70fP1\">HPV<\/a>\u00a0vaccine<\/li>\n<li><span class=\"il\">The<\/span>\u00a0Salk\u00a0<a href=\"https:\/\/sph.umich.edu\/polio\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3Da2a711ac2d%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw1rjsKhrOWv2q4efQBMXlUv\">Polio<\/a>\u00a0vaccine<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2554544\/pdf\/bullwho00229-0146.pdf\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D193f62c8d5%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw07mO3bnLmB-iTf6XH4fua8\">Measles<\/a>\u00a0vaccine<\/li>\n<li><a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT00707148\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D2e7339de7d%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw2KcULsazeuKY7oqZTa45Pq\">Tdap<\/a>\u00a0vaccine<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8767431\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D5c1ba28577%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw0SyiBRp4rCDJv-cq9-r5B7\">COVID<\/a>\u00a0vaccine<\/li>\n<\/ul>\n<p>It is true that sometimes a new vaccine is tested against an existing vaccine, or a placebo may contain\u00a0an adjuvant, buffers, or stabilizers with a known safety record.<\/p>\n<p><a href=\"https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/94056\/9789241506250_eng.pdf;jsessionid=17ED1D2E5EF6423E9EA51B97B8126F88?sequence=1\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D9e421016fb%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw2OtGwTcPXaoJVcErgDLjqL\"><span class=\"il\">The<\/span>\u00a0World Health Organization<\/a>\u00a0guides\u00a0<span class=\"il\">the<\/span>\u00a0ethical use of placebos in vaccine trials in certain situations. It is acceptable when no effective vaccine is available\u00a0and\u00a0<span class=\"il\">the<\/span>\u00a0new vaccine is intended to benefit\u00a0<span class=\"il\">the<\/span>\u00a0population being studied.<\/p>\n<p>However, using placebos is considered unacceptable when there is already an effective and safe vaccine accessible in\u00a0<span class=\"il\">the<\/span>\u00a0public health system of\u00a0<span class=\"il\">the<\/span>\u00a0country where\u00a0<span class=\"il\">the<\/span>\u00a0trial is planned. In such cases, it would be unethical to withhold\u00a0<span class=\"il\">the<\/span>\u00a0existing vaccine from participants if not receiving it would pose a significant risk to their health.<\/p>\n<p><span class=\"il\">The<\/span>\u00a0tweet cites examples like Prevnar-13 and Gardasil, suggesting that their safety profiles were not adequately assessed because\u00a0<span class=\"il\">the<\/span>\u00a0control groups received other vaccines or adjuvants. Prevnar-13 was licensed based on a trial comparing it to\u00a0<a href=\"https:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/rr5911a1.htm\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D6b0cd6d8e0%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw0BnnSs1sJ70jFJiNF1LY0j\">Prevnar-7<\/a>, which was already effective in preventing certain diseases caused by pneumococci.<\/p>\n<p>It would have been\u00a0<a href=\"https:\/\/pauloffit.substack.com\/p\/the-casual-cruelty-of-placebo-controlled\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D718ffc6dee%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw2yDwbD8E9YNbUkx0o9iYa_\">unethical<\/a>\u00a0to use a saline placebo for Prevnar-13 when a vaccine was already available that provided significant protection against\u00a0<a href=\"https:\/\/www.nfid.org\/infectious-diseases\/pneumococcal-disease-and-children\/#:~:text=Pneumococcal%20disease%20can%20range%20from,brain%20damage%2C%20and%20limb%20amputation.\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D629e7efea3%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw0hNTbALGrzBegKg7R81yKZ\">severe bacterial infection<\/a>. Purposely leaving children at risk, without their knowledge, when an approved vaccine with a known safety record was available would have meant purposely allowing children to get sick and worse.<\/p>\n<p>Furthermore,\u00a0<span class=\"il\">the<\/span>\u00a0CDC\u2019s definition of placebo is consistent with\u00a0<span class=\"il\">the<\/span>\u00a0accepted scientific understanding of\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4157320\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3Dcaba96c89a%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw3mrfpuwRv8lnNGvvlcZ8vF\">placebos in vaccine trials<\/a>. Inert placebos, such as saline solution, are commonly used, but in some cases, an active control, such as another vaccine, may be used to protect\u00a0<span class=\"il\">the<\/span>\u00a0health of participants.<\/p>\n<p>It may be difficult to convince an ardently anti-vaccine person of\u00a0<span class=\"il\">the<\/span>\u00a0value of non-saline placebos because they enter\u00a0<span class=\"il\">the<\/span>\u00a0conversation already believing that vaccines writ large are dangerous.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Vaccines are sometimes tested against other vaccines or adjuvants instead of saline placebos to protect participants&#8217; health when an effective vaccine is already available.<\/p>\n","protected":false},"parent":0,"template":"","jtf_topic_subjects":[205,199,204,196,191,203,216,218],"class_list":["post-10668","jtf_topics","type-jtf_topics","status-publish","hentry","jtf_topic_subjects-chickenpox","jtf_topic_subjects-childhood-vaccines","jtf_topic_subjects-dtap","jtf_topic_subjects-hpv","jtf_topic_subjects-measles","jtf_topic_subjects-mmr","jtf_topic_subjects-pneumonia","jtf_topic_subjects-vaccine-safety","entry","no-media"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/jtf_topics\/10668","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/jtf_topics"}],"about":[{"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/types\/jtf_topics"}],"version-history":[{"count":4,"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/jtf_topics\/10668\/revisions"}],"predecessor-version":[{"id":10948,"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/jtf_topics\/10668\/revisions\/10948"}],"wp:attachment":[{"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/media?parent=10668"}],"wp:term":[{"taxonomy":"jtf_topic_subjects","embeddable":true,"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/jtf_topic_subjects?post=10668"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}