{"id":14709,"date":"2025-07-31T18:48:22","date_gmt":"2025-07-31T23:48:22","guid":{"rendered":"https:\/\/www.voicesforvaccines.org\/?post_type=jtf_topics&#038;p=14709"},"modified":"2025-07-31T18:48:22","modified_gmt":"2025-07-31T23:48:22","slug":"were-childhood-vaccines-properly-tested","status":"publish","type":"jtf_topics","link":"https:\/\/www.voicesforvaccines.org\/es\/jtf_topics\/were-childhood-vaccines-properly-tested\/","title":{"rendered":"Were childhood vaccines properly tested?"},"content":{"rendered":"<div class=\"wpb-content-wrapper\">[vc_row source=&#8221;&#8221; text=&#8221;Clinical Trials&#8221; font_container=&#8221;tag:h2|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; google_fonts=&#8221;font_family:Abril%20Fatface%3Aregular|font_style:400%20regular%3A400%3Anormal&#8221; link=&#8221;&#8221; css=&#8221;.vc_custom_1708910874436{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;}&#8221;][vc_column][vc_row_inner][vc_column_inner][vc_custom_heading text=&#8221;The Claim:&#8221; font_container=&#8221;tag:h3|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221;][vc_column_text css=&#8221;&#8221;]Following last week&#8217;s Senate Oversight Committee hearing,\u00a0<a href=\"https:\/\/x.com\/ChildrensHD\/status\/1948752095869612131\" target=\"_blank\" rel=\"noopener\">anti-vaxxers<\/a>\u00a0claim\u00a0that vaccines on the childhood schedule were never tested in real science experiments using a true placebo, but instead were only compared to older vaccines or had no real comparison at all.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner][vc_custom_heading text=&#8221;The Facts:&#8221; font_container=&#8221;tag:h3|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221;][vc_column_text css=&#8221;&#8221;]The claim\u00a0that most childhood vaccine trials use other vaccines as controls, which are immunologically active and not inert placebos. In reality, saline-placebo-controlled trials are conducted for many vaccines to assess both\u00a0<a href=\"https:\/\/www.voicesforvaccines.org\/toolkits\/vaccine-overview-development-safety\/\" target=\"_blank\" rel=\"noopener\">safety<\/a>\u00a0and efficacy:<\/p>\n<ul>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9142061\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D9b4a4b97e3%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw32oSp_dVw5AFEA2hLObqz2\">Rubella<\/a>\u00a0vaccine<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3893185\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D1314eaff2f%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw2PV3wc84z5i8otVAT5ijJB\">Pneumococcal<\/a>\u00a0vaccine<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2233906\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3Dd9bfacac6f%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw3B47LWEmeZJ9UFuSp41fnZ\">Hib<\/a>\u00a0vaccines<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17484215\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D0a8f83150d%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw3S7pEL9M4FoVxfSXW70fP1\">HPV<\/a>\u00a0vaccine<\/li>\n<li>The\u00a0Salk\u00a0<a href=\"https:\/\/sph.umich.edu\/polio\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3Da2a711ac2d%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw1rjsKhrOWv2q4efQBMXlUv\">Polio<\/a>\u00a0vaccine<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2554544\/pdf\/bullwho00229-0146.pdf\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D193f62c8d5%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw07mO3bnLmB-iTf6XH4fua8\">Measles<\/a>\u00a0vaccine<\/li>\n<li><a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT00707148\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D2e7339de7d%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw2KcULsazeuKY7oqZTa45Pq\">Tdap<\/a>\u00a0vaccine<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8767431\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D5c1ba28577%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw0SyiBRp4rCDJv-cq9-r5B7\">COVID<\/a>\u00a0vaccine<\/li>\n<\/ul>\n<p>It is true that sometimes a new vaccine is tested against an existing vaccine, or a placebo may contain\u00a0an adjuvant, buffers, or stabilizers with a known safety record.<\/p>\n<p><a href=\"https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/94056\/9789241506250_eng.pdf;jsessionid=17ED1D2E5EF6423E9EA51B97B8126F88?sequence=1\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D9e421016fb%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw2OtGwTcPXaoJVcErgDLjqL\">The\u00a0World Health Organization<\/a>\u00a0guides\u00a0the\u00a0ethical use of placebos in vaccine trials in certain situations. It is acceptable when no effective vaccine is available\u00a0and\u00a0the\u00a0new vaccine is intended to benefit\u00a0the\u00a0population being studied.<\/p>\n<p>However, using placebos is considered unacceptable when there is already an effective and safe vaccine accessible in\u00a0the\u00a0public health system of\u00a0the\u00a0country where\u00a0the\u00a0trial is planned. In such cases, it would be unethical to withhold\u00a0the\u00a0existing vaccine from participants if not receiving it would pose a significant risk to their health.<\/p>\n<p>An example would be\u00a0like Prevnar-13 and how it was\u00a0licensed based on a trial comparing it to\u00a0<a href=\"https:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/rr5911a1.htm\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D6b0cd6d8e0%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw0BnnSs1sJ70jFJiNF1LY0j\">Prevnar-7<\/a>, which was already effective in preventing certain diseases caused by pneumococci.<\/p>\n<p>It would have been\u00a0<a href=\"https:\/\/pauloffit.substack.com\/p\/the-casual-cruelty-of-placebo-controlled\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D718ffc6dee%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw2yDwbD8E9YNbUkx0o9iYa_\">unethical<\/a>\u00a0to use a saline placebo for Prevnar-13 when a vaccine was already available that provided significant protection against\u00a0<a href=\"https:\/\/www.nfid.org\/infectious-diseases\/pneumococcal-disease-and-children\/#:~:text=Pneumococcal%20disease%20can%20range%20from,brain%20damage%2C%20and%20limb%20amputation.\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3D629e7efea3%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw0hNTbALGrzBegKg7R81yKZ\">severe bacterial infection<\/a>. Purposely leaving children at risk, without their knowledge, when an approved vaccine with a known safety record was available would have meant purposely allowing children to get sick and worse.<\/p>\n<p>Furthermore,\u00a0the\u00a0CDC\u2019s definition of placebo is consistent with\u00a0the\u00a0accepted scientific understanding of\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4157320\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/voicesforvaccines.us6.list-manage.com\/track\/click?u%3De17a65409cd8f13ba7e58cc97%26id%3Dcaba96c89a%26e%3Dfc0735be13&amp;source=gmail&amp;ust=1690295150789000&amp;usg=AOvVaw3mrfpuwRv8lnNGvvlcZ8vF\">placebos in vaccine trials<\/a>. Inert placebos, such as saline solution, are commonly used, but in some cases, an active control, such as another vaccine, may be used to protect participants&#8217; health.<\/p>\n<p>It may be difficult to convince an ardently anti-vaccine person of\u00a0the\u00a0value of non-saline placebos because they enter\u00a0the\u00a0conversation already believing that vaccines writ large are dangerous.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Many childhood vaccines were tested with saline placebos. When not, ethical reasons\u2014like protecting kids from disease\u2014guided the use of active controls.<\/p>\n","protected":false},"parent":0,"template":"","jtf_topic_subjects":[199,194,218],"class_list":["post-14709","jtf_topics","type-jtf_topics","status-publish","hentry","jtf_topic_subjects-childhood-vaccines","jtf_topic_subjects-vaccine-ingredients","jtf_topic_subjects-vaccine-safety","entry","no-media"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/jtf_topics\/14709","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/jtf_topics"}],"about":[{"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/types\/jtf_topics"}],"version-history":[{"count":1,"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/jtf_topics\/14709\/revisions"}],"predecessor-version":[{"id":14728,"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/jtf_topics\/14709\/revisions\/14728"}],"wp:attachment":[{"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/media?parent=14709"}],"wp:term":[{"taxonomy":"jtf_topic_subjects","embeddable":true,"href":"https:\/\/www.voicesforvaccines.org\/es\/wp-json\/wp\/v2\/jtf_topic_subjects?post=14709"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}