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Was my COVID vaccine tested?

The Claim:

Old claims that COVID vaccines were not properly tested and may be unsafe point mainly to the idea that the vaccines had dangerous levels of residual DNA—up to 500 times more than what the FDA and WHO allow.

The Facts:

The concerns about changes in the vaccines tested when they became the vaccines given out are unfounded. Manufacturing a small number of vaccines for a trial is different from manufacturing thousands of doses at a time. Process 1 is the small batch process, while process 2 is the scaled-up version. Although the processes are different, they are both held to the same safety and quality standards, and the vaccines they make have to be the same.

Original claims that DNA plasmids were found in mRNA vaccines at a higher proportion of mRNA to DNA than is allowed by FDA guidelines stem from a previous preprint paper acknowledging that one limitation of the study is the “unknown provenance of the vaccine vials under study.”

They also note that the vaccines arrived without proper cold chain processes and were all expired. They follow up that paper with this preprint, where the authors obtained and tested “24 unopened expired vials” and “three vials of in-date remnants.” As mRNA degrades much faster than DNA, especially when held in suboptimal conditions, any proportion of trace amounts of DNA used in manufacturing would be amplified in expired vials, as these were,  or ones not held in optimal conditions.

Disclaimer: Science is always evolving and our understanding of these topics may have evolved too since this was originally posted. Be sure to check out our most recent posts and browse the latest Just the Facts Topics for the latest.

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